646523-18-4

Basic information

• Product Name: (4S,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester
• Synonyms: (4S,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester
• CAS NO: 646523-18-4
• Molecular Weight: 366.455
• Mol File: 646523-18-4.mol

Chemical Properties

• CAS DataBase Reference: (4S,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester(646523-18-4)
• EPA Substance Registry System: (4S,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester(646523-18-4)

Safety Data

• Hazardous Substances Data: 646523-18-4(Hazardous Substances Data)

Upstream product

• 1057719-63-7 4-(4-methoxybenzyloxy)-2-methylbutanal 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 646523-19-5 tert-Butyl-(5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-ynyloxy)-dimethyl-silane 
• 646523-23-1 tert-Butyl-((Z)-5-{(4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-pent-3-enyloxy)-dimethyl-silane 
• 1026697-44-8 Trifluoro-methanesulfonic acid (4R,5R)-5-[(R)-3-(4-methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 646523-22-0 {(4R,5R)-5-[(R)-3-(4-Methoxy-benzyloxy)-1-methyl-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 

Relevant articles and documents

Asymmetric Total Synthesis of Attenol A and B

The asymmetric total synthesis of attenol A (1) and B (2), which possess challenging structures and an interesting biological activity, was accomplished in a convergent and highly stereo-selective manner (de, ee ≥ 96%) with good overall yield. The short total synthesis is based on asymmetric alkylations of SAMP-hydrazones as well as a Sharpless asymmetric dihydroxylation as key steps.