646530-52-1Relevant academic research and scientific papers
Synthesis and biological evaluation of S-acyl-3-thiopropyl prodrugs of N-phosphonoacetyl-L-aspartate (PALA)
Gagnard, Valerie,Leydet, Alain,Le Mellay, Veronique,Aubenque, Marielle,Morere, Alain,Montero, Jean-Louis
, p. 883 - 891 (2007/10/03)
The synthesis of new prodrugs of PALA characterised by the presence of S-acyl-3-thiopropyl, as enzyme-labile groups on the phosphonate moiety of PALA, is reported. The cytotoxic activities of PALA prodrugs were determined against human cell line (SW1573 lung carcinoma cells). A number of prodrugs bearing S-pivaloyl as acyl groups displayed cytotoxic activity in the same order of magnitude of PALA.
