64658-05-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-chloroquinoline is used as an intermediate for the synthesis of various antimalarial and antibacterial drugs. Its antimicrobial and antiparasitic properties make it a valuable component in the development of these medications.
Used in Agrochemical Industry:
2-Bromo-4-chloroquinoline is used as an intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Fine Chemicals Development:
2-Bromo-4-chloroquinoline is utilized in the development of other fine chemicals, showcasing its versatility as a building block in various chemical reactions and processes.
Used in Dyes and Fluorescent Materials Production:
2-Bromo-4-chloroquinoline serves as a crucial building block in the production of dyes and fluorescent materials, highlighting its importance in the chemical industry for creating specialized products with unique properties.

InChI:InChI=1/C9H5BrClN/c10-9-5-7(11)6-3-1-2-4-8(6)12-9/h1-5H

Upstream product

• 20151-40-0 2,4-dibromoquinoline 
• 4637-59-6 4-Chloroquinoline N-oxide 
• 611-35-8 4-chloroquinoline 

Downstream Products

• 1379615-33-4 2‐(1-(4‐(trifluoromethoxy)benzyl)-1H-pyrazol‐4-yl)quinolin‐4(1H)‐one 
• 1379615-38-9 3-chloro-2-(1‐(4-(trifluoromethoxy)benzyl)‐1H‐pyrazol-4‐yl)quinolin‐4(1H)-one 
• 1379615-59-4 4‐chloro‐2‐(1‐(4-(trifluoromethoxy)benzyl)‐1H‐pyrazol‐4‐yl)quinoline 
• 1379615-36-7 2-(1‐(4‐fluorobenzyl)-1H-pyrazol‐4‐yl)quinolin‐4(1H)‐one 
• 1379615-62-9 4-chloro-2‐(1‐(4-fluorobenzyl)-1H‐pyrazol‐4-yl)quinoline 
• 1361968-34-4 C₂₇H₂₅F₃N₄O₂ 
• 1361968-33-3 4-chloro-2-(6-((4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)methyl)pyridin-3-yl)quinoline 

Relevant academic research and scientific papers

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties

A series of 2-pyrazolyl quinolones has been designed and synthesized in 5-7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compounds display no cross-resistance with multidrug resistant parasite strains (W2) compared to drug sensitive strains (3D7), with IC50 (concentration of drug required to achieve half maximal growth suppression) values in the range of 15-33 nM. Furthermore, members of the series retain moderate activity against the atovaquone-resistant parasite isolate (TM90C2B). The described 2-pyrazoyl series displays improved DMPK properties, including improved aqueous solubility compared to previously reported quinolone series and acceptable safety margin through in vitro cytotoxicity assessment. The 2-pyrazolyl quinolones are believed to bind to the ubiquinone-reducing Qi site of the parasite bc1 complex, which is supported by crystallographic studies of bovine cytochrome bc1 complex.

ANTIMALARIAL COMPOUNDS

The present invention relates to antimalarial compounds. More specifically, the present invention relates to novel substituted quinolone derivatives of formula (I) and related quinoline derivatives of formula (II) as defined herein that possess potent ant