6466-94-0Relevant articles and documents
Bauerenol acetate, the pentacyclic triterpenoid from tabernaemontana longipes, is an antitrypanosomal agent
Carothers, Simira,Nyamwihura, Rogers,Collins, Jasmine,Zhang, Huaisheng,Park, Hajeung,Setzer, William N.,Ogungbe, Ifedayo Victor
, (2018)
The Latin American plant Tabernaemontana longipes was studied in this work as a potential source of antiparasitic agents. The chloroform extract of T. longipes leaves was separated into several fractions, and tested for antitrypanosomal activity. One of the fractions displayed significant growth inhibitory activity against Trypanosoma brucei. The active principle in the fraction was isolated, purified, and characterized by NMR and mass spectrometry. The antitrypanosomal agent in the CHCl3 extract of T. longipes leaves is the pentacyclic triterpenoid bauerenol acetate. A metabolite profiling assay suggest that the triterpenoid influences cholesterol metabolism. The molecular target(s) of bauerenol and its acetate, like many other antiparasitic pentacyclic triterpenoids is/are unknown, but they present privileged structural scaffolds that can be explored for structure-based activity optimization studies using phenotypic assays.
Indole alkaloids and terpenoids from Tabernaemontana markgrafiana
Nielsen,Hazell,Hazell,Ghia,Torssell
, p. 1729 - 1735 (2007/10/02)
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Triterpene constituents of Tabernaemontana laurifolia and Haplophyton cimicidum
Cava,Shubber,Rao, Kota V.
, p. 1301 - 1303 (2007/10/12)
The triterpene bauerenyl acetate was isolated directly by crystallization from the non-polar neutral extract of the bark of Tabernaemontana laurifolia D.C. A similar extract of Haplophyton cimicidum (whole plant) yielded, after chromatography, the triterpenes erythrodiol monostearate, bauerenol and betulin, as well as the steroid β-sitosterol.
