64663-49-6Relevant academic research and scientific papers
A sulfone-based strategy for the preparation of 2,4-disubstituted furan derivatives
Haines, Nathan R.,VanZanten, Aaron N.,Cuneo, Anthony A.,Miller, John R.,Andrews, William J.,Carlson, David A.,Harrington, Ryan M.,Kiefer, Adam M.,Mason, Jeremy D.,Pigza, Julie A.,Shaun Murphree
, p. 8131 - 8137 (2011/11/28)
2,4-Disubstituted furans are prepared by treating 2,3-dibromo-1- phenylsulfonyl-1-propene (DBP, 2) with 1,3-diketones under basic conditions. The furan-forming step involves a deacetylation, and the selectivity of this process depends upon the steric demand of the R group. The substituent in position 4 is elaborated by reaction of sulfonyl carbanions with alkyl halides, acyl halides, and aldehydes. Oxidative or reductive desulfonylation produces the 2,4-disubstituted furans in 60-92% yield. This strategy has been used to prepare rabdoketone A (12) and the naturally occurring nematotoxic furoic acid 13. (Figure presented)
Synthesis and some reactions of furo[2,3-c]pyrylium salts
Voshchula,Golyak,Dulenko
, p. 560 - 563 (2007/10/03)
Furo[2,3-c]pyrylium perchlorates were synthesized by acylation of α-(3-furyl) ketones, and their transformations under the action of ammonia and alkali were studied. 1996 MAEe Cyrillic signΚ Hayκa/Interperiodica Publishing.
