64686-87-9Relevant academic research and scientific papers
Synthesis and antitumor screening of novel 3-phenylthiazolo [4,5-d]pyrimidin-2-thione derivatives
Becan, Lilianna,Wagner, Edwin
experimental part, p. 521 - 528 (2009/04/07)
A series of new derivatives of 3-phenylthiazolo[4,5-d]pyrimidine-2-thiones were synthesized by the cyclization of 4-amino-5-alkyl(aryl) carboxamido-2,3-dihydrothiazolo-2-thione with aromatic aldehydes. Amine moieties were substituted in position 7 of the obtained bicyclic compounds. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, and 13C-NMR spectral data. Some of the newly synthesized compounds were selected by the US National Cancer Institute for in vitro antitumor screening. The two compounds 3d 7-chloro-5-(4-fluorophenyl)-3- phenyl-4,5-dihydro-3H-thiazolo[4,5-d]pyrimidine-2-thione and 4i 5-(2-chlorophenyl)-7-(4-fluorobenzylamino)-3-phenyl-4,5-dihydro-3H-thiazolo[4, 5-d]pyrimidine-2-thione proved to be the most active in the present study and their antitumor activities against 60 human tumor cell lines were described. ECV Editio Cantor Verlag.
Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5 d)pyrimidin-7(6H) one-2(3H)-thiones
Devani,Shishoo,Pathak,Parikh,Radhakrishnan,Padhya
, p. 1652 - 1655 (2007/10/09)
4-Amino-5-substituted thiazole-2(3h)-thiones and thiazolo(4,5-d)-pyrimdin-7(6H) -one-2(3H)-thiones have been synthesized and screened for antimicrobial and pharmacological activities. Significant analgesic, antiinflammatory, anticonvulsant and antimicrobi
