646989-68-6Relevant academic research and scientific papers
SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases
Shelke, Nilesh B.,Ghorpade, Ramrao,Pratap, Ajay,Tak, Vijay,Acharya
, p. 31226 - 31230 (2015)
N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na2CO3 (1:1) is found to achieve maximum conversion by refluxing for 3 hours in water. The product can be easily isolated by solvent extraction.
ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS
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Page/Page column 60-61, (2015/06/25)
The present invention is directed to acylguanidines which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPHl), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY
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Page/Page column 46, (2010/02/15)
2,4-Diaminoquinazolines of formulae I-IV and VI (I, II, III, IV and VI) are useful for treating spinal muscular atrophy (SMA).
