647002-92-4Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists
Ye, Xiang-Yang,Li, Yi-Xin,Farrelly, Dennis,Flynn, Neil,Gu, Liqun,Locke, Kenneth T.,Lippy, Jonathan,O'Malley, Kevin,Twamley, Celeste,Zhang, Litao,Ryono, Denis E.,Zahler, Robert,Hariharan, Narayanan,Cheng, Peter T.W.
scheme or table, p. 3545 - 3550 (2009/04/06)
Several series of substituted dehydropiperidine and piperidine-4-carboxylic acid analogs have been designed and synthesized as novel, potent dual PPARα/γ agonists. The SAR of these series of analogs is discussed. A rare double bond migration occurred during the basic hydrolysis of the α,β-unsaturated dehydropiperidine esters 12, and the structures of the migration products were confirmed through a series of 2D NMR experiments.
