647010-99-9Relevant academic research and scientific papers
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics
Sun, Haiying,Nikolovska-Coleska, Zaneta,Chen, Jianyong,Yang, Chao-Yie,Tomita, York,Pan, Hongguang,Yoshioka, Yoshiko,Krajewski, Krzysztof,Roller, Peter P.,Wang, Shaomeng
, p. 793 - 797 (2007/10/03)
Structure-based design, chemical synthesis and biochemical testing of a series of novel Smac peptido-mimetics as inhibitors of XIAP protein are described. The most potent compound, 6j, has a binding affinity (Ki value) of 24 nM to XIAP BIR3 pro
