6473-56-9Relevant academic research and scientific papers
New 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: Synthesis and SAR study for their antileishmanial activity
Tahghighi, Azar,Emami, Saeed,Razmi, Sepide,Rezazade Marznaki, Farzane,Kabudanian Ardestani, Sussan,Dastmalchi, Siavoush,Kobarfard, Farzad,Shafiee, Abbas,Foroumadi, Alireza
, p. 843 - 852 (2013/07/26)
A novel series of 5-(5-nitrofuran-2-yl)-and 5-(5-nitrothiophen-2-yl)-1,3,4- thiadiazole-2-amines bearing acyclic amine at C-2 position of thiadiazole ring were synthesized and evaluated in vitro against promastigote and amastigote forms of Leishmania major. The structure-activity of series was investigated by studying 40 compounds. The most active derivatives were hydroxypropylamino-and methoxypropylamino-analogs of 5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole (compounds 29 and 32, respectively) with highest selectivity index (SI >12).
