64730-24-1Relevant academic research and scientific papers
Practical palladium-mediated deprotective method of allyloxycarbonyl in aqueous media
Genet, Jean Pierre,Blart, Errol,Savignac, Monique,Lemeune, Stephane,Lemaire-Audoire, Sandrine,Paris, Jean-Marc,Bernard, Jean-Marie
, p. 497 - 503 (1991)
The Allyloxycarbonyl (Alloc) moiety can be removed smoothly and selectively in good yield (73-100%) from allylic esters, carbamates and carbonates by aqueous Pd (O) catalysed allyl transfer to diethylamine in aqueous media employing a water soluble phosphine. The allyl scavenger as well as by product allyl diethylamine are volatile and easily removed in vacuo. In a two phase system an increased selectivity is seen. The method has been successfully used for deprotection of a wide range of secondary amines or base sensitive derivatives and the catalyst is efficiently recycled.
