647376-90-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 119-62-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 
• 89711-08-0 N-(t-butoxycarbonyl)glycinal 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 768398-52-3 [(1S,2S)-1-(Dimethoxy-phosphoryloxymethyl)-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 1193376-04-3 (1S,2S)-(+)-2-tert-butoxycarbonylamino-3-O-tert-butyldimethylsilyl-1-(4-nitrophenyl)-1,3-propanediol 
• 1186120-59-1 tert-butyl (1S,2S)-3-amino-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate 
• 1335122-94-5 C₂₂H₃₄N₄O₉ 
• 1335123-08-4 C₃₁H₄₃N₅O₁₀ 
• 1335123-07-3 C₃₄H₄₉N₅O₉ 
• 1335123-06-2 C₃₇H₄₇N₅O₉ 
• 1335123-05-1 C₃₁H₄₃N₅O₁₀ 
• 1335123-04-0 C₃₁H₄₃N₅O₁₀ 
• 1335123-03-9 C₃₄H₄₉N₅O₉ 
• 1335123-02-8 C₂₈H₄₅N₅O₁₀ 
• 1335123-00-6 C₂₈H₃₈N₄O₉ 
• 1335122-99-0 C₂₈H₃₈N₄O₈ 
• 1335122-96-7 C₂₂H₃₄N₄O₈S 

Relevant academic research and scientific papers

Amine-catalyzed asymmetric cross-aldol reactions using heterofunctionalized acetaldehydes as nucleophiles

Various heterofunctionalized acetaldehydes were successfully employed in an amine-catalyzed asymmetric cross-aldol reaction, affording a variety of synthetically useful 1,2-difunctionalized compounds such as 1,2-diols and 1,2-aminoalcohols. With this method, both syn- and anti-1,2-difunctionalized compounds were obtained from the same set of reactants by using the appropriate amine catalyst.

Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine

Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S,2S)-2-amino-1-(4-n

Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors

Herein we report a series of novel chloramphenicol amine derivatives as aminopeptidase N (APN)/CD13 inhibitors. All compounds were synthesized starting from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol. The preliminary biologi

Density functional theory calculations of the optical rotation and electronic circular dichroism: The absolute configuration of the highly flexible trans-isocytoxazone revised

(Chemical Equation Presented) Ab initio calculations of the optical rotation (OR) and electronic circular dichroism (ECD) for a series of trans-diastereomers of the natural cytokine modulator cytoxazone 1-4 have been performed by density functional theory

Synthesis and biological properties of novel sphingosine derivatives

Sphingosine-1-phosphate (S-1P) derivatives such as threo-(2S,3S)-analogues, which are C-3 stereoisomers of natural erythro-(2S,3R)-S-1P, have been synthesized starting from l-serine or (1S,2S)-2-amino-1-aryl-1,3-propanediols (6). threo-(1S,2R)-2-Amino-1-aryl-3-bromopropanols (HBr salt) have also been prepared from 6. The threo-S-1Ps and the threo-amino-bromide derivatives have shown potent inhibitory activity against Ca2+ ion mobilization in HL60 cells induced by erythro-S-1P, suggesting that these compounds would compete with cell surface EDG/S1P receptors.

Synthetic studies on d-biotin. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine

A novel and convenient method for the stereoselective synthesis of d-biotin 1 starting from the commercially available cis-1,3-dibenzyl-2- imidazolidone-4,5-dicarboxylic acid 2 has been developed. The key features of this synthesis include the enantioselective reduction of a meso-cyclic imide, mediated by a chiral oxazborolidine catalyst, derived from (1S,2S)-(+)-threo-1- (4-nitrophenyl)-2-amino-1,3-propanediol and the direct introduction of a C 5 side chain to the (3aS,6aR)-thiolactone through a modified di-Grignard reaction. Enantioselectivities of 98% in the oxazborolidine- catalyzed asymmetric reduction process have been achieved.