64740-68-7

Basic information

• Product Name: 1,4-Dihydroxymidazolam
• Synonyms: 1,4-Dihydroxymidazolam;8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol;Ro 22-0284;8-chloro-6-(2-fluorophenyl)-1-(hydroxymethyl)-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
• CAS NO: 64740-68-7
• Molecular Formula: C18H13ClFN3O2
• Molecular Weight: 357.7661232
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 64740-68-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: >195?C (dec.)
• Boiling Point: 595.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• PKA: 12.69±0.40(Predicted)
• CAS DataBase Reference: 1,4-Dihydroxymidazolam(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydroxymidazolam(64740-68-7)
• EPA Substance Registry System: 1,4-Dihydroxymidazolam(64740-68-7)

Safety Data

• Hazardous Substances Data: 64740-68-7(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Upstream product

• 59467-70-8 Midazolam 

Relevant articles and documents

Simultaneous determination and pharmacokinetics of midazolam and its hydroxymetabolites in plasma and urine of man and dog by means of high-performance liquid chromatography

A HPLC (high performance liquid chromatography) method for the determination of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) and its hydroxy metabolites has been developed. The half-life of elimination of midazolam and the glucuronides of the metabolites 1-hydroxymethyl-midazolam, 4-hydroxy-midazolam and 1-hydroxymethyl-4-hydroxy-midazolam are identical, 53 min in dogs and 90 min in man.