64747-70-2Relevant academic research and scientific papers
Metal-free18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation
Yuan, Gengyang,Wang, Feng,Stephenson, Nickeisha A.,Wang, Lu,Rotstein, Benjamin H.,Vasdev, Neil,Tang, Pingping,Liang, Steven H.
supporting information, p. 126 - 129 (2016/12/27)
A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C-H activation of benzylic C-H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.
Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination
Ma, Jing-Jing,Yi, Wen-Bin,Lu, Guo-Ping,Cai, Chun
supporting information, p. 2890 - 2894 (2015/04/27)
An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.
Silver-catalyzed oxidative activation of benzylic C-H bonds for the synthesis of difluoromethylated arenes
Xu, Peng,Guo, Shuo,Wang, Liyan,Tang, Pingping
supporting information, p. 5955 - 5958 (2014/06/10)
A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic C-H bonds has been developed. Utilizing AgNO3 as the catalyst, various arenes with diverse functional groups undergo activation/fluorination of ben
