6476-89-7Relevant academic research and scientific papers
Organocatalytic Mannich-type reactions of trifluoroethyl thioesters
Utsumi, Naoto,Kitagaki, Shinji,Barbas III, Carlos F.
supporting information; experimental part, p. 3405 - 3408 (2009/04/21)
(Chemical Equation Presented) Direct organocatalytic Mannich-type reactions of thioesters provide for the expedient and diastereoselective synthesis of protected β-amino acids. A variety of thioesters were found to be reactive with different lmines under mild conditions to provide β-amino acids in good yields. This chemistry was extended to a diastereo- and enantioselective variant.
