64762-39-6Relevant academic research and scientific papers
1,3-CYCLOADDITION OF BENZONITRILE OXIDES TO DIAZEPINES. I. 1-ETHOXYCARBONYL-5-METHYL-1,2-DIAZEPINE
Beltrame, Paolo,Cadoni, Enzo,Carnasciali, Maria M.,Gelli, Gioanna,Lai, Adolfo,et. al
, p. 1583 - 1604 (2007/10/02)
Stable aryl nitrile oxides (1a-e) and 1-ethoxycarbonyl-5-methyl-1,2-diazepine (2) undergo 1,3-cycloaddition reactions to give isomeric 1,2,4-oxadiazole (3), 4,5-dihydroisoxazole (4) and isoxazole (5) derivatives, the first one being in any case the most abundant product.Overall kinetics were measured at temperatures in the range 50-90 deg C, in 1,1,2,2-tetrachloroethane and mixtures of the latter with DMF; rate coefficients for the parallel reactions were, thus, obtained.Substituent and solvent effects are discussed.
