64781-22-2

Upstream product

• 67-36-7 4-phenoxy benzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Design and Assembly of a Hierarchically Micro-and Mesoporous MOF as a Highly Efficient Heterogeneous Catalyst for Knoevenagel Condensation Reaction

A 3D hierarchically micro-and mesoporous MOF, [Tb6(μ3-OH)8·(2-FBA)2·(H2O)6·(DCBA)2]·10DMF·4H2O (namely, Tb-DCBA), was successfully constructed by the coordination self-assembly process between H4DCBA linker and Tb6 hexanuclear cluster. By virtue of preferable physicochemical stability, high surface area, multiple porosity, and abundant amino functional groups, Tb-DCBA is not merely considered as a greatly potential heterogeneous catalyst for Knoevenagel condensation reaction, but also has remarkable repeatability for reusing at least four times. It is worth noting that micro-and mesoporous MOF is still an urgent and enormous challenge, because such MOFs are difficult to synthesize and determine precise structures, and always possess relatively poor stability to limit their practical applications. Hence, this work creates a scarce opportunity for a hierarchically micro-and mesoporous MOF for investigating its catalytic performance.

An Amino-Functionalized Metal-Organic Framework, Based on a Rare Ba12(COO)18(NO3)2 Cluster, for Efficient C3/C2/C1 Separation and Preferential Catalytic Performance

A barium(II) metal-organic framework (MOF) based on a predesigned amino-functionalized ligand, namely [Ba2(L)(DMF)(H2O)(NO3)1/3]?DMF?EtOH?2 H2O (UPC-33) [H3L=4,4′-((2-amino-5-carboxy-1,3-phenylene)bis(ethyne-2,1-diyl))dibenzoic acid] has been synthesized. UPC-33 is a 3-dimensional 3,18-connected network with fcu topology with a rare twelve-nuclear Ba12(COO)18(NO3)2 cluster. UPC-33 shows permanent porosity and a high adsorption heat of CO2 (49.92 kJ mol?1), which can be used as a platform for selective adsorption of CO2/CH4 (8.09). In addition, UPC-33 exhibits high separation selectivity for C3 light hydrocarbons with respect to CH4 (228.34, 151.40 for C3H6/CH4, C3H8/CH4 at 273k and 1 bar), as shown by single component gas sorption and selectivity calculations. Due to the existence of ?NH2 groups in the channels, UPC-33 can effectively catalyze Knoevenagel condensation reactions with high yield, and substrate size and electron dependency.

Amino-functionalized MOFs with high physicochemical stability for efficient gas storage/separation, dye adsorption and catalytic performance

A major goal of metal-organic framework (MOF) research is to adjust the structure and function for specific applications. It is highly desirable to develop new multifunctional MOF materials for selective guest molecule storage/separation and catalysis. Recent advances in the synthesis of MOFs have created new opportunities in this direction. Although many multifunctional MOFs have been synthesized to explore different applications, it is still a challenge to construct MOFs with high physicochemical stability for specific applications. In addition, most of the MOFs only have a microporous structure, which is not conducive to the transportation of substances and the entry of macromolecules, thus limiting the applications of these materials in macromolecular adsorption. Herein, we present three amino-functionalized InIII/AlIII/ZrIV-based MOFs with high physicochemical stability for multifunctional performances. The pore size of these MOFs varies from a few angstroms to the nanometre scale, and their specific surface areas and pore volumes gradually increase with the change of nodes. Further studies reveal that these MOFs are promising candidates as storage mediums for hydrogen (H2) and as separation agents for the selective removal of (C3Hn-C2Hn) from natural gas (NG). The mesoporous Zr-MOF can effectively enrich dye molecules to purify water, and the adsorption dynamics of a series of organic dyes shows that there are no size and charge-selective effects for the adsorption process. Furthermore, the catalytic efficiency and mechanism of Knoevenagel condensation reactions have also been studied in detail. Overall, the three versatile amino-functionalized MOFs highlight the advantages of metal-organic frameworks for designing host materials tailored for applications in hydrogen (H2) storage, light hydrocarbon adsorption/separation, water purification, and catalysis.

Preparation method of Ibrutinib intermediate 4-amino-3-(4-phenoxy) phenyl-1H-pyrazol [3,4-d] pyrimidine

The invention relates to a preparation method of an Ibrutinib intermediate 4-amino-3-(4-phenoxy) phenyl-1H-pyrazol [3,4-d] pyrimidine. The method is characterized in that 4-phenoxybenzaldehyde is adopted as the original raw material; 4-phenoxybenzaldehyde and malononitrile achieve dehydration condensation, and 2-cyano-3-(4-phenoxy) phenyl acrylonitrile (II) is generated; 2-cyano-3-(4-phenoxy) phenyl acrylonitrile (II) and hydrazine hydrate achieve cyclization, and 5-amino-3-(4-phenoxy) phenyl-4-cyano-2,3-2h-pyrazole (III) is obtained; the compound III is subjected to formamide condensation and then is subjected to oxidation, and 4-amino-3-(4-phenoxy) phenyl-1H-pyrazol [3,4-d] pyrimidine (I) is obtained; or the compound III is firstly subjected to oxidation and then is subjected to formamide condensation, and the object compound is obtained. According to the preparation method, the utilized raw materials are low in price and easy to obtain, the one-pot method is adopted, reaction conditions are moderate, and the method is easy to operate, safe and environment-friendly in technology, good in reaction selectivity, high in product purity, low in cost, and suitable for industrial production.

A Stable Amino-Functionalized Interpenetrated Metal-Organic Framework Exhibiting Gas Selectivity and Pore-Size-Dependent Catalytic Performance

An amino-functionalized doubly interpenetrated microporous zinc metal-organic framework (UPC-30) has been solvothermally synthesized. UPC-30 can be stable at 190 °C and confirmed by powder X-ray diffraction. Gas adsorption measurements indicate that UPC-3