Uridine, 2'-O-(2-methoxyethyl)-2-thiois a modified nucleoside derived from uridine, featuring a 2-thiolinkage and a 2-methoxyethyl group at the 2' position. This modification enhances the stability and pharmacokinetic properties of RNA molecules, making them more resistant to degradation and improving their cellular uptake. It is a valuable tool in the development of RNA-based therapeutics and research applications.
647839-20-1
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Basic information
- Product Name: Uridine, 2'-O-(2-methoxyethyl)-2-thio-
- Synonyms:
- CAS NO:647839-20-1
- Molecular Formula: C12H18N2O6S
- Molecular Weight: 318.351
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Uridine, 2'-O-(2-methoxyethyl)-2-thio-(CAS DataBase Reference)
- NIST Chemistry Reference: Uridine, 2'-O-(2-methoxyethyl)-2-thio-(647839-20-1)
- EPA Substance Registry System: Uridine, 2'-O-(2-methoxyethyl)-2-thio-(647839-20-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 647839-20-1(Hazardous Substances Data)
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647839-20-1 Usage
Uses
Used in Pharmaceutical Industry:Uridine, 2'-O-(2-methoxyethyl)-2-thiois used as a building block for the synthesis of modified RNA molecules, particularly in the development of antisense oligonucleotides and siRNA. The modification enhances the stability and pharmacokinetic properties of these RNA molecules, making them more resistant to degradation and improving their cellular uptake, which is crucial for their therapeutic efficacy.
Used in Research Applications:
In the field of research, Uridine, 2'-O-(2-methoxyethyl)-2-thiois utilized for the synthesis of modified RNA molecules to study their interactions with cellular machinery and to investigate the mechanisms of gene regulation and RNA interference. This modification allows researchers to design and test novel RNA-based tools and therapeutics with improved properties compared to unmodified RNA molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 647839-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,7,8,3 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.Calculate Digit Verification of CAS Registry Number 647839-20:
(8*6)+(7*4)+(6*7)+(5*8)+(4*3)+(3*9)+(2*2)+(1*0)=201
201 % 10 = 1
So 647839-20-1 is a valid CAS Registry Number.
647839-20-1Upstream product
647839-20-1Downstream Products
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Uridine, 2'-O-(2-methoxyethyl)-2-thio-
