647851-48-7Relevant academic research and scientific papers
125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid: Synthesis and preliminary tissue distribution
Yamamoto, Fumihiko,Kuwano, Eri,Kaneshiro, Tetsuo,Sasaki, Shigeki,Maeda, Minoru
, p. 737 - 750 (2003)
Three 125I-labeled 2-O- and 3-O-m-iodobenzyl, and 6-O-m-iodophenyl derivatives of L-ascorbic acid were prepared by melt exchange procedures in isolated radiochemical yields of 12-60% after HPLC purification. Biodistribution studies in tumor-bearing mice showed very different in vivo tissue uptake properties from previous results obtained with 14C-labeled ascorbic acid and 6-deoxy-6-[18F]fluoro-L-ascorbic acid. None of these seems to be suitable radioiodinated analogs of L-ascorbic acid for imaging study of its in vivo biochemistry. Copyright
