647854-13-5Relevant academic research and scientific papers
Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands
Gilligan, Paul J.,Folmer, Beverly K.,Hartz, Richard A.,Koch, Stephanie,Nanda, Kausik K.,Andreuski, Stephen,Fitzgerald, Lawrence,Miller, Keith,Marshall, William J.
, p. 4093 - 4102 (2003)
The syntheses and rat CRF receptor binding affinities of 'retro-pyrazolotriazine' corticotropin-releasing factor (CRF) ligands 4 are reported. Some have high affinity for rat CRF receptors (Ki≤10 nM). The data provide additional support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.
