647857-39-4

Usage

Uses

Used in Organic Synthesis:
Methyl (2R,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate is utilized as a reagent in organic synthesis for its ability to facilitate the creation of complex organic molecules. The Boc protecting group and the methyl ester functionality enhance the compound's reactivity and versatility in various chemical reactions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Methyl (2R,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate serves as a key intermediate in the development of new drugs. Its unique structure and properties make it a promising candidate for the synthesis of bioactive compounds with potential therapeutic applications.
Used in the Synthesis of Fluorinated Compounds:
Due to the presence of a fluorine substituent, Methyl (2R,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate is employed in the synthesis of fluorinated compounds, which often exhibit enhanced biological activity and metabolic stability compared to their non-fluorinated counterparts. This makes it a valuable tool in the design of novel pharmaceutical agents and agrochemicals.
Used in Chiral Synthesis:
The (2R,4S) stereochemistry of Methyl (2R,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylate makes it a useful chiral building block for the asymmetric synthesis of enantiomerically pure compounds. This is particularly important in the pharmaceutical industry, where the stereochemistry of a molecule can significantly impact its biological activity and safety profile.

Upstream product

• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 2584-71-6 cis-hydroxy-D-proline 
• 114676-47-0 (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester 
• 189160-59-6 N-tert-butoxycarbonyl-trans-4-(trifluoromethylsulfonyloxy)-L-proline methyl ester 

Downstream Products

• 1143504-73-7 C₅H₈FNO₂*ClH 
• 1201580-69-9 6-[(2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidin-1-yl]-9H-purine 
• 1201581-81-8 tert-butyl (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine-1-carboxylate 
• 1201581-82-9 (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine 
• 681128-50-7 (2R,4S)-1-(tert- butoxycarbonyl)- 4- fluoropyrrolidine- 2-carboxylic acid 
• 869527-46-8 4-(S)-fluoro-2-(R)-hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER

Described herein are triazalone compounds of Formula (I) and pharmaceutically acceptable salts thereof. Methods of making and using compounds of Formula (I) are also described. Compounds of Formula (I) and pharmaceutically acceptable salts thereof can be

METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF

Compounds that modulate GluR5 activity and methods of using the same are disclosed.

Novel pyrrolidone derivatives for use as MetAP-2 inhibitors

Compounds of the formula (I), in which R, X, Y, Z, R3 and R4 have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.

COMPOUNDS CONTAINING FUSED RINGS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.

Practical syntheses of 4-fluoroprolines

4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the routes provide process-scale access to these useful nonnatural amino acids.

BACE INHIBITORS

The present invention provides BACE inhibitors of Formula (I): methods for their use and preparation, and intermediates for their preparation.

N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.