64793-86-8

Upstream product

• 924-50-5 Methyl 3,3-dimethylacrylate 
• 541-47-9 3-Methylbutenoic acid 
• 108-98-5 thiophenol 

Downstream Products

• 95553-23-4 3-methyl-3-(phenylthio)butan-1-ol 
• 1270009-53-4 N-[3,4-dihydro-4-(hydroxymethyl)-2,2,4-trimethyl-2H-1-benzothiopyran-6-yl]-N'-(4-nitrophenyl)thiourea 
• 1270009-64-7 N-[3,4-dihydro-4-(acetoxymethyl)-2,2,4-trimethyl-2H-1-benzothiopyran-6-yl]-N'-(4-nitrophenyl)thiourea 
• 111139-38-9 fumitremorgin B 
• 116696-87-8 C₂₇H₂₉N₃O₂S 
• 112445-99-5 C₂₇H₂₉N₃O₂S 
• 111427-85-1 1-(2-methyl-2-phenylthiopropyl)-3-methoxycarbonyl-β-carboline 
• 111433-90-0 (1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 
• 116611-97-3 (S)-2-{(S)-1-Methoxycarbonyl-2-[6-methoxy-2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 116612-00-1 (S)-2-{(S)-1-Methoxycarbonyl-2-[2-(3-methyl-3-phenylsulfanyl-butyryl)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 111427-92-0 (1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 
• 106211-91-0 Demethoxyfumitremorgin C 
• 111427-85-1 (1S,3S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 
• 111468-02-1 (1S,3S)-1-(2-Methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of N-[3,4-dihydro-4-(acetoxymethyl)-2,2,4-trimethyl-2H-1- benzothiopyran-6-yl]-N'-(4-nitrophenyl)thiourea and N-[3,4-dihydro-4- (hydroxymethyl)-2,2,4-trimethyl-2H-1-benzothiopyran-6-yl]-N'-(4-nitrophenyl) thiourea, a Major Metabolite of N-(3,4-d

The compound N-(3,4-dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)- N'-(4-nitrophenyl)thiourea [NSC 726189] has exhibited strong anticancer activity in several assays and cell lines and is under consideration for clinical trials for the possible tr

Fluoride ion-catalyzed conjugate addition for easy synthesis of 3-sulfanylpropionic acid from thiol and α,β-unsaturated carboxylic acid

3-Sulfanylpropionic acids are obtained in excellent yields by proceeding through a simple, mild, and efficient procedure utilizing tetrabutylammonium fluoride (TBAF) as catalyst.

Fluoroboric acid adsorbed on silica-gel (HBF4-SiO2) as a new, highly efficient and reusable heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds

Fluoroboric acid adsorbed on silica-gel (HBF4-SiO2) has been found to be a new and highly efficient heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds under solvent-free conditions. In the case of

Iodine catalyzed conjugate addition of mercaptans to α,β- unsaturated carboxylic acids under solvent-free condition

We have described herein molecular iodine catalyzed Michael addition of thiol to α,β-unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3-Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner.

Synthesis of 2,2-Dimethyl-2H-thiochromenes, the Sulfur Analogs of Precocenes

A new general synthesis of 2,2-dimethyl-2H-thiochromenes in good yield consists of the Michael addition of thiophenols to 3-methyl-2-butenoic acid, intramolecular cyclocondensation of the resultant 3-methyl-3-phenylthiobutanoic acids, reduction of the 2,2-dimethyl-4-oxothiochromenes thus obtained with sodium borohydride, and acid-catalyzed dehydration of the resultant 4-hydroxy-2,2-dimethylthiochromans.