6480-64-4Relevant academic research and scientific papers
Transketolase Catalyzed Synthesis of N-Aryl Hydroxamic Acids
Fúster Fernández, Inés,Hecquet, Laurence,Fessner, Wolf-Dieter
, p. 612 - 621 (2021/12/08)
Hydroxamic acids are metal-chelating compounds that show important biological activity including anti-tumor effects. We have recently engineered the transketolase from Geobacillus stearothermopilus (TKgst) to convert benzaldehyde as a non-natur
Rhodium(III)-catalyzed regioselective C–H nitrosation/annulation of unsymmetrical azobenzenes to synthesize benzotriazole N-oxides via a RhIII/RhIII redox-neutral pathway
Zhang, Yuanfei,Chen, Zhe-Ning,Su, Weiping
supporting information, (2021/05/19)
A Rh(III)-catalyzed regioselective C–H nitrosation/annulation reaction of unsymmetrical azobenzenes with [NO][BF4] has been developed to achieve high-yielding syntheses of benzotriazole N-oxides with excellent functional group tolerance. Computational studies have revealed that this oxidative C–H functionalization reaction involves an interesting redox-neutral Rh(III)/Rh(III) pathway without the change of Rh oxidation state.
Light-operated ligand based on quinolone structure and application thereof
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Paragraph 0068; 0124-0126; 0128, (2021/08/19)
The invention relates to the technical field of biology, in particular to a novel light-operated ligand based on a quinolone structure and a preparation method and application thereof. The invention provides the light-operated ligand based on the quinolone structure or an isomer prodrug, a solvate and a pharmaceutically acceptable salt of the light-operated ligand based on the quinolone structure; and the structural formula of the light-operated ligand based on the quinolone structure is A-linker-B, wherein A is a transmembrane domain ligand structure, and B is a light-operated element; and linker is a linear subunit which is inactive to a light-operated ligand based on the quinolone structure. Azobenzene and a quinolone cannabinoid receptor skeleton are connected through a proper linker, so that the ligand configuration is changed under an illumination condition, and the excitation state of a cannabinoid receptor is regulated and controlled.
Enantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis
Chen, Wanting,Wang, Yanni,Mi, Xueling,Luo, Sanzhong
supporting information, p. 8178 - 8182 (2019/10/16)
An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo-and enantiocontrol.
