64820-47-9

Basic information

• Product Name: 4-(4-bromophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine
• Synonyms: 4-(4-bromophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine
• CAS NO: 64820-47-9
• Molecular Formula: C₂₁H₁₆BrNS
• Molecular Weight: 394.32744
• Mol File: 64820-47-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-bromophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(64820-47-9)
• EPA Substance Registry System: 4-(4-bromophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(64820-47-9)

Safety Data

• Hazardous Substances Data: 64820-47-9(Hazardous Substances Data)

Upstream product

• 2403-27-2 1-(4-bromophenyl)-3-phenyl-2-propen-1-one 
• 137-07-5 2-amino-benzenethiol 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 
• 72758-69-1 (E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one 

Relevant articles and documents

Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium

A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The

'On water' synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS)

An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol in water under neutral conditions catalysed by SDS. Excellent chemoselectivity was observed for substrates possessing halogen atoms or nitro/alkoxy/thioalkyl groups which did not undergo competitive aromatic nucleophilic substitution of the halogen atoms or the nitro group, reduction of the nitro or the α,β-unsaturated carbonyl group, or dealkylation of the alkoxy/thioalkoxy groups.

2,4-DIARYL-2,3-DIHYDROBENZOTHIAZEPINES

2,4-Diaryl-2,3-dihydrobenzothiazepines are obtained in a single stage from chalcones and ortho-aminothiophenol in the presence of triethylamine.The nature of the electronic transitions in their UV absorption spectra is discussed with the use of quantum-chemical methods.It was shown that the seven-membered ring does not invert in the range of temperatures between -80 and +140 deg C and is in the boat form.The main initial event in the fragmentation of the molecules of the obtained compounds under electron impact is the formation of benzothiazole-containing radicalions.In an acidic medium 2,4-diphenyl-2,3-dihydrobenzothiazepine is hydrolyzed to 3-(2-aminophenylthio)-1,3-diphenyl-1-propanone, and in its reaction with 2,4-dinitrophenylhydrazine chalcone hydrazone and o-aminothiophenol are formed.