64821-97-2Relevant academic research and scientific papers
Design, synthesis, and antimicrobial activity of novel spiroisoxazolo[2,3- b[[1,2,4]thiadiazole-2,2-thiazolidine-4-ones and spiroisoxazolo[2,3-b[[1,2,4] oxadiazole-2, 2-thiazolidine-4-ones
Eligeti, Rajanarendar,Saini, Ramakrishna,Dharavath, Nagaraju
, p. 427 - 438 (2012/10/29)
A new synthetic strategy for the synthesis of novel 6-methyl-3-aryl spiro[isoxazolo[2,3-b][1,2,4]thiadiazole-2,2-thiazolidin]-4-ones (9a-9e) and 6-methyl-3-aryl spiro[isoxazolo[2,3-b][1,2,4]oxadiazole-2,2-thiazolidin]-4-ones (12a-12e) analogs is described. These compounds showed significant antimicrobial activity against all the standard strains.
Mononuclear heterocyclic rearrangements. Part 11. Rearrangements of 1,2,4-oxadiazoles, isoxazoles, and 1,2,5-oxadiazoles involving a sulphur atom
Vivona, Nicolo,Cusmano, Giuseppe,Macaluso, Gabriella
, p. 1616 - 1619 (2007/10/04)
The reactions of 3-amino-5-methyl- and 3-amino-5-phenyl-1,2,4-oxadiazoles, 3-amino-5-methylisoxazole, and 3-amino-4-methyl- and 3-amino-4-phenyl-1,2,5- oxadiazoles with phenyl isothiocyanate have been investigated, and the reactivity of phenylthioureido-derivatives (3) of these ring systems towards rearrangement have been studied. The presence of a sulphur atom in the side-chain sequence (1; XYZ = NCS) greatly enhances the reactivity of the systems under consideration towards rearrangement. The tendency of the three heterocycles to rearrange decreases in the order 1,2,4-oxadiazole > isoxazole > 1,2,5-oxadiazole.
