64829-09-0

Basic information

• Product Name: 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine
• Synonyms: 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine
• CAS NO: 64829-09-0
• Molecular Formula: C₈H₅ClN₄
• Molecular Weight: 192.61
• Mol File: 64829-09-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 392.8°C at 760 mmHg
• Flash Point: 191.4°C
• Appearance: /
• Vapor Pressure: 2.23E-06mmHg at 25°C
• CAS DataBase Reference: 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine(64829-09-0)
• EPA Substance Registry System: 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine(64829-09-0)

Safety Data

• Hazardous Substances Data: 64829-09-0(Hazardous Substances Data)

Usage

General Description

2-Amino-6-chloro-3,5-dicyano-4-methylpyridine is a chemical compound with a molecular formula C7H3ClN4. It is a pyridine derivative with a chlorine atom at the 6th position, an amino group at the 2nd position, and cyano groups at the 3rd and 5th positions. 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential antifungal and antibacterial properties. Additionally, it is used in the production of dyes and pigments, and in certain organic reactions as a key reactant. Due to its unique chemical structure, 2-Amino-6-chloro-3,5-dicyano-4-methylpyridine plays a crucial role in several industrial and research applications.

InChI:InChI=1/C8H5ClN4/c1-4-5(2-10)7(9)13-8(12)6(4)3-11/h1H3,(H2,12,13)/p+1

Upstream product

• 75-07-0 acetaldehyde 
• 109-77-3 malononitrile 
• 86694-64-6 N,N,N,N'-Tetramethylacetimidinium salt of 1,1,3,3-tetracyano-2-methyl-1-propene 
• 78-39-7 Triethyl orthoacetate 
• 84655-58-3 4-chloro-2,7-dimethyl-5,7-diaza-1,3,5-octatriene-1,1,3-tricarbonitrile 

Downstream Products

• 101375-08-0 N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid diethyl ester 
• 101348-20-3 N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid 
• 101348-00-9 N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamic acid 
• 101810-81-5 5,10-dimethyl-5-deazafolic acid 
• 101810-79-1 5-methyl-5-deazamethotrexate 

Relevant articles and documents

Tetrachlorosilane and zinc chloride as a binary reagent for the preparation of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives

[Figure not available: see fulltext.] A green one-pot method for efficient synthesis of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives was developed, based on stirring of various aldehydes and malononitrile with tetrachlorosilane and zinc chloride under solvent-free conditions at room temperature for 3–10 h. The effects of zinc chloride and the reaction conditions were studied. Compounds were characterized by X-ray analysis and NMR spectroscopy.

5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin

It is disclosed that 5-methyl-5-deazamethotrexate and 5-methyl-5-deaza-10-ethylaminopterin are more than 10 times as potent as 5-deazamethotrexate in the L1210 cell growth inhibition test.

REACTION OF DIMETHYLFORMAMIDE AND DIMETHYLACETAMIDE DIETHYL ACETALS WITH MALONONITRILE

In the reaction of N,N-dimethylacetamide diethyl acetal with malononitrile the dimethylammonium salt (or the N, N, N', N'-tetramethylacetamidinium salt with an excess of the acetal) of 2-methyl-1,1,3,3-propenetetracarbonitrile was obtained in addition to α-cyano-β-dimethylaminocrotononitrile.Its structure was proved by 1H and 13C NMR spectroscopy and mass spectrometry and also by its conversion into 2-chloro-4-methyl-3,5-dicyano-6-aminopyridine.The reaction of dimethylformamide diethyl acetal with malononitrile takes place similarly.