64830-43-9Relevant academic research and scientific papers
CLEAVAGE OF PEPTIDE TO SPARROW-RESIN BOND BY CATALYTIC TRANSFER HYDROGENOLYSIS WITH 1,4-CYCLOHEXADIENE
Colombo, Roberto
, p. 1119 - 1122 (1980)
Cleavage of benzyl ester-type linkage to the Sparrow modified polystyrene support was attempted with the aid of catalytic transfer hydrogenation using 1,4-cyclohexadiene and palladium black, and satisfactory yields were obtained.This will provide an alternatively efficient and mild method for the final deblocking step during improved solid phase peptide synthesis.
Method for cleaving the peptide-resin bond in solid phase peptide synthesis by hydrogenolysis
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, (2008/06/13)
An improved process for cleaving peptides bound to a polymer by way of a benzylester linkage during solid phase peptide synthesis, the improvement comprising hydrogenolysis of said linkage by catalytic hydrogenation using a palladium (II) salt with a weak acid anion as the catalyst.
