648442-43-7Relevant articles and documents
3-Alkyl- and 3-aryl-(7-oxo-7H-furo [3,2-g]chromen-5-yl)alkanoic acids as inhibitors of leukotriene B4 biosynthesis
Koerner, Paul
, p. 273 - 284 (2007/10/03)
The synthesis and biological properties of 3-alkyl- and 3-aryl-(7-oxo-7H-furo[3,2-g]chromen-5-yl)alkanoic acids are described. The compounds were evaluated for their ability to inhibit soybean 15-lipoxygenase (15-LO) and the production of leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes. The furocoumarins were further investigated for their lipophilicity and their capacity to photobleach N,N-dimethyl-p-nitrosoaniline (RNO) after irradiation with UVA light. The synthesised furocoumarins showed only a moderate ability to inhibit the 15-LO and the production of LTB4. The 3-alkyl substituted furocoumarins had a higher capacity to photobleach RNO than then the 3-aryl substituted furocoumarinso. The inhibitory activity of the new compounds was quite modest in comparison to other known inhibitors of 15-LO and LTB4 production. Nevertheless, they may provide the basis for the development of more potent antiinflammatory potential photoreactive furocoumarins.
