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N-tosyl-L-phenylglycine, also known as N-tosyl-L-phenylalanine, is a synthetic amino acid derivative that plays a significant role in organic chemistry and pharmaceutical research. It is a chiral compound, meaning it has a non-superimposable mirror image, and is characterized by the presence of a tosyl (tosylate) group attached to the nitrogen atom of the amino group, and a phenyl group attached to the alpha carbon. N-tosyl-L-phenylglycine is often used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals due to its unique reactivity and stereochemistry. N-tosyl-L-phenylglycine is also employed in the study of enzyme mechanisms and as a resolving agent in the separation of enantiomers, highlighting its importance in the field of asymmetric synthesis and drug development.

6485-48-9

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6485-48-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6485-48-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,8 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6485-48:
(6*6)+(5*4)+(4*8)+(3*5)+(2*4)+(1*8)=119
119 % 10 = 9
So 6485-48-9 is a valid CAS Registry Number.

6485-48-9Relevant academic research and scientific papers

A new access to 3,5-disubstituted piperazinones via Pd(0)-catalyzed amination

Ferber, Benoit,Lemaire, Sébastien,Mader, Mary M.,Prestat, Guillaume,Poli, Giovanni

, p. 4213 - 4216 (2007/10/03)

An original synthetic route toward 3,5-disubstituted piperazinones has been developed. The method relies upon a 6-exo intramolecular process between a sulfonylated nitrogen atom of amino acid derivation and an η3-allyl-palladium moiety. This cyclization process generates the two possible (cis and trans) diastereoisomers whose ratio depends on the amino acid employed. The bulkier the amino acid residue, the higher the observed cis:trans ratio. Convincing evidence for reversible intramolecular addition of the nitrogen nucleophile to the η3-allyl-palladium complex is put forward.

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