64856-26-4

Basic information

• Product Name: 2-(methylsulfonyl)-N-phenylacetamide
• CAS NO: 64856-26-4
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 213.2535
• Mol File: 64856-26-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 506.7°C at 760 mmHg
• Flash Point: 260.3°C
• Density: 1.332g/cm³
• Vapor Pressure: 2.16E-10mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 2-(methylsulfonyl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methylsulfonyl)-N-phenylacetamide(64856-26-4)
• EPA Substance Registry System: 2-(methylsulfonyl)-N-phenylacetamide(64856-26-4)

Safety Data

• Hazardous Substances Data: 64856-26-4(Hazardous Substances Data)

Usage

Chemical class

Sulfonamide drugs, which are antimicrobial agents.

Molecular weight

229.25 g/mol

Derivative of

Acetamide, with a phenyl group and a sulfonyl group attached to the nitrogen atom.

Potential uses

Analgesic and anti-inflammatory drug, efficacy in treating various inflammatory and pain-related conditions.

Mechanism of action

Inhibiting the production of prostaglandins involved in the inflammatory response.

Investigation for potential use

Treatment for certain cancers and neurological disorders.

Upstream product

• 62-53-3 aniline 
• 2386-57-4 methanesulfonic acid sodium salt 
• 587-65-5 N-chloroacetyl-aniline 

Downstream Products

• 2987-49-7 2-(methylsulfonyl)aniline 

Relevant articles and documents

N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide

A herbicide containing as the active ingredient an N-(henylsulfonyl)picolinamide derivative represented by general formula (I) wherein X reprcsents a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, a C1-4 haloalkoxy, a (C1-4 alkoxy)carbonyl, a [di(C1-4 alkyl)amino]sulfonyl, an [N—(C1-4 alkyl)-N—(C1-4 alkoxy)amino]sulfonyl, a (C1-4 alkylamino)sulfonyl, a C1-4 alkylthio, a C1-4 alkylsulfinyl, a C1-4 alkylsulfonyl, or nitro; n is an integer of 0 to 5; Y represets a halogeno, a C1-4 alkyl, a C1-4 haloalkyl, a C1-4 alkoxy, C1-4 haloalkoxy, a C1-4 alkylthio, a C1-4 haloalkylthio, amino, a C1-4 alkylamino, a di(C1-4 alkyl)amino, a (C1-4 alkoxy) C1-4 alkyl, a (C1-4 alkylthio) C1-4 alkyl, or nitro; and m is an integer of 0 to 4. This active ingredient is synthesized by condensing a substituted picolinic acid with a substituted benzenesulfonamide under dehydration, or by reacting the phenyl ester of a substituted picolinic acid with a substituted benzenesulfonamide in the presence of a basic compound.

Replacement of a chlorine with a methylsulfonyl group in the metabolism of propachlor (2-chloro-N-isopropylacetanilide).

Urine from rats and sheep given single doses of [14C]propachlor contained 14C metabolites in which the chlorine of propachlor was replaced by a methylsulfonyl group. Methylsulfonyl-containing metabolites were also isolated from the urine of rats given an intraperitoneal dose of the cysteine conjugate of [14C]propachlor; this indicated that the methylsulfonyl-containing metabolites resulted from metabolic reactions subsequent to the mercapturic acid pathway.