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(5Z,13E,15S)-6,9α-Epithio-11α,15-dihydroxyprosta-5,13-dien-1-oic acid, also known as 6,9-Thiaprostacyclin, 9(O)-Thiaprostacyclin, PGI2-S, or TPGI2, is a synthetic analog of prostacyclin (PGI2) where the oxygen atom in the 6,9-ether bridge is replaced by sulfur, forming an epithio moiety. This structural modification enhances its stability compared to the naturally occurring prostacyclin, which is highly labile. (5Z,13E,15S)-6,9α-Epithio-11α,15-dihydroxyprosta-5,13-dien-1-oic acid retains biological activity as a vasodilator and platelet aggregation inhibitor, acting through the prostacyclin receptor (IP receptor) to stimulate adenylate cyclase and increase cyclic AMP levels. Its improved stability makes it a valuable tool for studying prostacyclin-mediated pathways and potential therapeutic applications in cardiovascular diseases.

64868-63-9

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64868-63-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 64868-63-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,8,6 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 64868-63:
(7*6)+(6*4)+(5*8)+(4*6)+(3*8)+(2*6)+(1*3)=169
169 % 10 = 9
So 64868-63-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O4S/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1

64868-63-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (5Z)-6,9-thiaprostacyclin

1.2 Other means of identification

Product number -
Other names 5-[(3aR,4R,5R,6aS)-5-Hydroxy-4-((E)-(S)-3-hydroxy-oct-1-enyl)-hexahydro-cyclopenta[b]thiophen-(2Z)-ylidene]-pentanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64868-63-9 SDS

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