6487-93-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-CHLORO-PHENYL)-ACETAMIDINE HCL is used as a synthetic intermediate for the development of 5-HT2C receptor agonists. These agonists are valuable in the treatment of urinary incontinence, a condition that affects millions of people worldwide. 2-(4-CHLORO-PHENYL)-ACETAMIDINE HCL's role in the synthesis of these agonists highlights its importance in addressing a significant medical need.
Additionally, 2-(4-CHLORO-PHENYL)-ACETAMIDINE HCL is utilized in the convenient and quick synthesis of 1,3,5-triazine compounds. These compounds are known for their diverse applications, including their use as pharmaceuticals, agrochemicals, and dyes. The efficient synthesis of 1,3,5-triazine compounds using 2-(4-CHLORO-PHENYL)-ACETAMIDINE HCL contributes to the advancement of chemical research and the development of new products in various industries.

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 87753-13-7 2-(4-Chloro-benzyl)-3,5,6,7-tetrahydro-cyclopentapyrimidin-4-one 
• 83217-77-0 2-p-chlorophenyl-4,6-dihydroxypyrimidine 
• 1220392-91-5 C₂₆H₂₅ClN₄O₃ 
• 1065113-76-9 7-benzyl-2-(4-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065113-73-6 7-benzyl-4-chloro-2-(4-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065110-69-1 2-(4-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065113-71-4 7-benzyl-2-(4-chlorobenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one 
• 23205-31-4 N-(2-2'-benzyloxyphenoxypropyl)-4-chlorophenylacetamidine p-toluenesulphonate 

Relevant academic research and scientific papers

Synthesis and anti cervical cancer activity of novel 5H-thiochromeno [4,3-d]pyrimidines

A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as1H NMR,13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.

Preparation method of 2-substituted phenyl-acetamidine hydrochloride

The invention discloses a preparation method of 2-substituted phenyl-acetamidine hydrochloride, comprising the following steps: preparing a Lewis acid intermediate by using trimethylaluminum or cuprous chloride with ammonium chloride, and reacting between