6487-99-6

Basic information

• Product Name: 2-(3-METHYLPHENOXY)ETHANAMINE
• Synonyms: [2-(3-methylphenoxy)ethyl]amine hydrochloride;2-(3-methylphenoxy)ethanamine(SALTDATA: HCl);2-(m-tolyloxy)ethanamine hydrochloride;2-(m-Tolyloxy)ethanamine
• CAS NO: 6487-99-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 6487-99-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 256.3°C at 760 mmHg
• Flash Point: 112.3°C
• Appearance: /
• Density: 1.008g/cm³
• Vapor Pressure: 0.0155mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.60±0.10(Predicted)
• CAS DataBase Reference: 2-(3-METHYLPHENOXY)ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-METHYLPHENOXY)ETHANAMINE(6487-99-6)
• EPA Substance Registry System: 2-(3-METHYLPHENOXY)ETHANAMINE(6487-99-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6487-99-6(Hazardous Substances Data)

Usage

General Description

2-(3-Methylphenoxy)ethanamine is a chemical compound with the molecular formula C10H15NO. This substance belongs to the class of organic compounds known as benzene and substituted derivatives, which are aromatic compounds containing one monocyclic ring system made of six carbon atoms, as found in benzene. 2-(3-Methylphenoxy)ethanamine is characterized by a benzene ring substituted by a methyl group and a phenoxy group. It is expected to be used in chemical synthesis and pharmaceutical manufacturing. Specific details about its physical properties or safety handling are not widely published, suggesting it might not be a common or well-studied substance. Its exact effects, toxicity, and potential uses may need further detailed and comprehensive studies.

InChI:InChI=1/C9H13NO/c1-8-3-2-4-9(7-8)11-6-5-10/h2-4,7H,5-6,10H2,1H3

Upstream product

• 6488-03-5 2-(2-(m-tolyloxy)ethyl)isoindoline-1,3-dione 
• 6512-13-6 1-(2-bromoethoxy)-3-methylbenzene 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 103524-19-2 2-Isopropyl-5-(2-m-tolyloxy-ethylamino)-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 
• 1066676-14-9 C₂₆H₂₈N₄O₂ 

Relevant articles and documents

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

Identification of N-(2-Phenoxyethyl)imidazo[1,2-a]pyridine-3-carboxamides as New Antituberculosis Agents

A series of imidazo[1,2-a]pyridine carboxamides (IPAs) bearing an N-(2-phenoxyethyl) moiety was designed and synthesized as new antitubercular agents. Seven 2,6-dimethyl IPAs demonstrated excellent in vitro activity (MIC: 0.025-0.054 μg/mL) against the drug susceptive H37Rv strain and two clinically isolated multidrug-resistant Mycobacterium tuberculosisstrains. Compound 10j displayed acceptable safety and pharmacokinetic properties, opening a new direction for further development.