6488-00-2

Usage

Uses

Used in Chemical Synthesis:
[2-(3-Chlorophenoxy)ethyl]amine is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its reactivity, particularly due to the chlorine atom, makes it a valuable component in the creation of new compounds with potential applications in these fields.
Used in Research Applications:
In the scientific community, [2-(3-Chlorophenoxy)ethyl]amine is employed as a research tool in the study of chemical reactions and mechanisms. Its unique structure and reactivity provide insights into the behavior of similar compounds and contribute to the development of new synthetic methods and strategies.
Used in Environmental Remediation:
[2-(3-Chlorophenoxy)ethyl]amine can be utilized in environmental remediation processes, where its reactivity may be harnessed to neutralize or break down harmful substances. This application is particularly relevant in the context of waste disposal and pollution control, where the compound's properties can be leveraged to mitigate environmental damage.
Used in Material Science:
In the field of material science, [2-(3-Chlorophenoxy)ethyl]amine is used as a component in the development of new materials with specific properties. Its unique structure and reactivity can contribute to the creation of materials with tailored characteristics, such as improved stability, enhanced reactivity, or novel functionalities.

InChI:InChI=1/C8H10ClNO/c9-7-2-1-3-8(6-7)11-5-4-10/h1-3,6H,4-5,10H2

Upstream product

• 108-43-0 3-monochlorophenol 
• 6488-01-3 2-(2-(3-chlorophenoxy)ethyl)isoindoline-1,3-dione 
• 6487-84-9 2-bromoethyl 3-chlorophenyl ether 

Downstream Products

• 113295-61-7 5-[2-(3-Chloro-phenoxy)-ethylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 

Relevant academic research and scientific papers

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1AReceptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and β-arrestin recruitment. Compounds 44 and 56 (2-methylaminophenoxyethyl and 2-(1H-indol-4-yloxy)ethyl derivatives, respectively) were selected as biased agonists with highly differential "signaling fingerprints"that translated into distinct in vivo profiles. In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt forced swimming test in rats. In contrast, compound 56 exhibited a first-in-class profile: it preferentially and potently activated β-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a component of "serotonergic syndrome". Both compounds showed promising developability properties. The presented 5-HT1A receptor-biased agonists, preferentially targeting various signaling pathways, have the potential to become drug candidates for distinct central nervous system pathologies and possessing accentuated therapeutic activity and reduced side effects.

1-(4-Substituted phenyl)-1H-imidazoles compounds

Novel 1-(4-substituted phenyl)-1H-imidazoles and their use as antiarrhythmic, anti-hypertensive and anti-ischemic agents is described. Pharmaceutical formulations containing such compounds are also discussed.