6488-00-2

Basic information

• Product Name: [2-(3-CHLOROPHENOXY)ETHYL]AMINE
• Synonyms: [2-(3-CHLOROPHENOXY)ETHYL]AMINE;RARECHEM AL BW 0342;[2-(3-chlorophenoxy)ethyl]amine hydrochloride;1-(2-Aminoethoxy)-3-chlorobenzene;MFCD11732332;2-(3-chlorophenoxy)ethanamine hydrochloride;2-(3-Chlorophenoxy)
• CAS NO: 6488-00-2
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.62
• Mol File: 6488-00-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 268.883°C at 760 mmHg
• Flash Point: 116.417°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.35±0.10(Predicted)
• CAS DataBase Reference: [2-(3-CHLOROPHENOXY)ETHYL]AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3-CHLOROPHENOXY)ETHYL]AMINE(6488-00-2)
• EPA Substance Registry System: [2-(3-CHLOROPHENOXY)ETHYL]AMINE(6488-00-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6488-00-2(Hazardous Substances Data)

Usage

General Description

"[2-(3-Chlorophenoxy)ethyl]amine" is a commonly used chemical compound in various industrial and scientific applications. It is an organic compound that is composed of a phenol group attached to an ethyl group via an ether linkage, with a chlorine atom attached to the phenol ring and an amine group attached to the ethyl chain. The presence of the chlorine atom provides this compound with unique reactivity, allowing it to participate in a variety of chemical reactions. While the compound is generally considered stable, it should be handled with care, as it can cause irritation and chemical burns when it comes in contact with skin or eyes. One must also take caution when disposing of this compound due to environmental considerations.

InChI:InChI=1/C8H10ClNO/c9-7-2-1-3-8(6-7)11-5-4-10/h1-3,6H,4-5,10H2

Upstream product

• 6488-01-3 2-(2-(3-chlorophenoxy)ethyl)isoindoline-1,3-dione 
• 6487-84-9 2-bromoethyl 3-chlorophenyl ether 
• 108-43-0 3-monochlorophenol 

Downstream Products

• 113295-61-7 5-[2-(3-Chloro-phenoxy)-ethylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 

Relevant articles and documents

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

1-(4-Substituted phenyl)-1H-imidazoles compounds

Novel 1-(4-substituted phenyl)-1H-imidazoles and their use as antiarrhythmic, anti-hypertensive and anti-ischemic agents is described. Pharmaceutical formulations containing such compounds are also discussed.