6488-26-2Relevant academic research and scientific papers
SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS
-
Page/Page column 34; 42; 46, (2015/06/03)
Described herein are certain steroid derivative compounds, for example of formula (I): wherein X1, X2, X3 L, and Ar are as defined herein, pharmaceutical compositions comprising such compounds, the use of such compounds and compositions to specifically target glucocorticoid action, and the use of such compounds and compositions in the treatment of acute and chronic inflammatory conditions, in particular rheumatoid arthritis, haematological and other malignancies, and for causing immunosuppression in the prevention or treatment of transplant rejection, as well as methods of preparing such compounds.
Synthesis and anticonvulsant evaluation of some N-substituted phthalimides
Wiecek, Malgorzata,Kiec-Kononowicz, Katarzyna
experimental part, p. 249 - 257 (2009/12/24)
Two series of phthalimides - one possessing an N-phenoxyalkyl moiety substituted at position 3 or 4 of the phenyl ring (1-9) and the other of N-alkenyl or alkinyl phthalimides (10-18) - were synthesized, evaluated for anticonvulsant activity and had their in silico lipophilicity estimated using computer programs. The anticonvulsant activity of phthalimides containing an unsaturated substituent at the phthalimide nitrogen was superior to that of the N-phenoxyalkyl phthalimides. Alkinyl derivative 10 emerged as the most active (in MES and ScMet tests) of all the compounds tested. A correlation between anticonvulsant activity and in silico estimated lipophilicity was not observed.
Synthesis of 5-Aryl-1,4-benzoxazepine and 6-Phenyl-2H-1,5-benzoxazocine Derivatives
Bremner, John B.,Browne, Elaine J.,Gunawardana, Indrani W. K.
, p. 129 - 141 (2007/10/02)
Four 5-aryl-2,3-dihydro-1,4-benzoxazepines (5a-d), with electron-releasing substituents, were prepared by a Bischler-Napieralski-type reaction of N-(2-aryloxyethyl)benzamides with phosphorus oxychloride in butanenitrile or ethanenitrile.Analogous 2,3-dihy
