64882-52-6

Usage

Uses

Used in Chemical Industry:
1-(1H-1,2,4-TRIAZOL-1-YL)ACETONE is used as a chelating agent for its ability to form stable complexes with metal ions, which is crucial in coordination chemistry for the synthesis of new compounds and materials.
Used in Corrosion Inhibition:
1-(1H-1,2,4-TRIAZOL-1-YL)ACETONE is used as a corrosion inhibitor for copper, providing protection against oxidation and degradation in various industrial settings where copper and its alloys are utilized.
Used in Plastics and Rubber Processing:
1-(1H-1,2,4-TRIAZOL-1-YL)ACETONE is used as a stabilizer in the processing of plastics and rubber, enhancing the durability and performance of these materials by preventing degradation from heat, light, and other environmental factors.
Used in Pharmaceutical Research:
1-(1H-1,2,4-TRIAZOL-1-YL)ACETONE is studied for its potential pharmaceutical properties, such as its antimicrobial effects, which could lead to the development of new treatments for bacterial infections.
Used in Antioxidant Applications:
1-(1H-1,2,4-TRIAZOL-1-YL)ACETONE is explored for its antioxidant capabilities, which may have implications for the prevention of oxidative stress-related diseases and the preservation of food products and other materials prone to oxidation.

InChI:InChI=1/C5H7N3O/c1-5(9)2-8-4-6-3-7-8/h3-4H,2H2,1H3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 78-95-5 chloroacetone 
• 126961-70-4 4-Amino-1-(2-oxo-propyl)-4H-[1,2,4]triazol-1-ium; bromide 
• 598-31-2 1-bromoacetone 

Downstream Products

• 104940-87-6 3-[1,2,4]Triazol-1-yl-but-3-en-2-one 

Relevant academic research and scientific papers

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic

Itraconazole (ITZ) is an FDA-approved member of the triazole class of antifungal agents. Two recent drug repurposing screens identified ITZ as a promising anticancer chemotherapeutic that inhibits both the angiogenesis and hedgehog (Hh) signaling pathways. We have synthesized and evaluated first- and second-generation ITZ analogues for their anti-Hh and antiangiogenic activities to probe more fully the structural requirements for these anticancer properties. Our overall results suggest that the triazole functionality is required for ITZ-mediated inhibition of angiogenesis but that it is not essential for inhibition of Hh signaling. The synthesis and evaluation of stereochemically defined des-triazole ITZ analogues also provides key information as to the optimal configuration around the dioxolane ring of the ITZ scaffold. Finally, the results from our studies suggest that two distinct cellular mechanisms of action govern the anticancer properties of the ITZ scaffold.

Efficient Synthesis of 6-(1H-1,2,4-Triazol-1-yl)-thieno[2,3-d]pyrimidin- 4(3H)-ones via an Iminophosphorane

Ethyl 2-amino-4-methyl-5-(1H-1,2,4-triazol-1-yl)thiophene-3-carboxylate 2, obtained from Gewald reaction of 1-(1H-1,2,4-triazol-1-yl)acetone 1 with ethyl cyanoacetate and sulfur, was transferred into iminophosphorane 3. Further reaction of 3 with aromatic isocyanates gave carbodiimides 4, which were treated subsequently with a secondary amine to give 6-(1H-1,2,4-triazol-1-yl)-thieno[2, 3-d]pyrimidin-4(3H)-ones 6 in good yields in the presence of a catalytic amount of sodium ethoxide. Copyright

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '