648899-30-3

Upstream product

• 102568-35-4 sodium 5-acetamido-1-naphthalenesulfonate 
• 52218-37-8 N-[5-(Chlorosulfonyl)-1-naphthalenyl]acetamide 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 648899-02-9 5-amino-naphthalene-1-sulfonic acid (4-chloro-phenyl)-amide 

Relevant academic research and scientific papers

Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors

HIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. In the present study, we have designed, synthesized and tested a series of caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Among these compounds, we found that HIV integrase inhibitory activities of compounds III-3 and III-4 were more potent than L-chicoric acid (IC50=11.8 μg/mL) and others were comparable to L-chicoric acid. Furthermore, the structure-activity relationships of these compounds were studied. The information gathered from this paper will be useful in the development and design of HIV-1 integrase inhibitors in the future.