64890-21-7Relevant academic research and scientific papers
Connecting a carbonyl and a π-conjugated group through a: P-phenylene linker by (5+1) benzene ring formation
Morofuji, Tatsuya,Kinoshita, Hanae,Kano, Naokazu
supporting information, p. 8575 - 8578 (2019/07/25)
A benzene ring was formed to connect a carbonyl group of various methyl ketones with a π-conjugated group through a p-phenylene linker. Methyl ketones and streptocyanines were used as the C1 and C5 sources, respectively, in the (5+1) annulation, which could form donor-π-acceptor molecules.
Synthesis of n-substituted carbonylamino-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents
Ghaffari, Mohammad A.,Ardley, Tiffany W.,Gangapuram, Madhavi,Redda, Kinfe K.
experimental part, p. 2615 - 2623 (2011/08/07)
Several N-substituted carbonyl/sulfonylamino-1,2,3,6-tetrahydropyridines (5a-i and 9a, b) were synthesized via sodium borohydride reduction of the corresponding N-substitutedimino-pyridinium ylides (4a-i and 8a, b) in absolute ethanol. Taylor &FrancisGroup, LLC.
Synthesis of Some N-(Phenylsulfonylamino)-1,2,3,6-tetrahydropyridines as Potential Anti-inflammatory Agents
Choi, JongOh,Wilson, Tiffany L.,Ly, Ana M.,Okoro, Cosmas O.,Onubogu, Udobi C.,Redda, Kinfe K.
, p. 281 - 295 (2007/10/03)
Several N-(phenylsulfonylamino)-1,2,3,6-tetrahydropyridines were synthesized by substituting a sulfonyl group for the carbonyl group of N-(phenylcarbonylamino)-1,2,3,6-tetrahydropyridines 1 in order to investigate the effect of the substitution on the analgesic and anti-inflammatory activities. Nucleophilic attack of pyridine derivatives 2 on 1-chloro-2,4-dinitrobenzene 3 furnished the pyridinium chlorides 4. Compound 4 and benzenesulfonyl hydrazide 5 were reacted to give the 2,4-dinitroanilino derivatives 6. Hydrolysis of 6 furnished the ylides 7. Sodium borohydride reduction of ylides afforded the tetrahydropyridines 8. Compound 8c was found to be the most active anti-inflammatory agent and was as potent as indomethacin, the reference compound. Compound 8f had the most significant hyperglycemic activity.
