648901-52-4Relevant academic research and scientific papers
α-substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents
Jain,Sundram,Lopez,Neckermann,Wu,Hackbarth,Chen,Wang,Ryder,Weidmann,Patel,Trias,White,Yuan
, p. 4223 - 4228 (2003)
We report the synthesis and biological activity of analogues of VRC3375 (N-hydroxy-3-R-butyl-3-[(2-S-(tert-butoxycarbonyl)-pyrrolidin-1-ylcarbonyl] propionamide), an orally active peptide deformylase inhibitor. This study explores the structure-activity relationship of various chelator groups, alpha substituents, P2′ and P3′ substituents in order to achieve optimal antibacterial activity with minimal toxicity liability.
