648930-90-9

Upstream product

• 178206-96-7 (R)-2-methoxycarbonylmethyl-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 1257235-22-5 3-(4-nitro-benzoyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 114676-67-4 (2S,4R)-1-Boc-4-[(t-butyldimethylsilyl)oxy]-2-(hydroxymethyl)pyrrolidine 
• 134441-71-7 (2S,4R)-1-boc-4-tert-butyldimethylsilylpyrrolidine-2-carbaldehyde 
• 1257234-66-4 2-(2-benzyloxycarbonylamino-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1257234-64-2 2-(2-benzyloxycarbonylamino-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1257234-68-6 3-(tert-butyl-dimethyl-silanyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 1257234-62-0 2-(2-benzyloxycarbonylamino-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 1257234-56-2 2-(2-benzyloxycarbonylamino-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1257234-58-4 2-(2-benzyloxycarbonylamino-ethyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1257234-60-8 2-(2-benzyloxycarbonylamino-ethyl)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1257234-70-0 3-hydroxy-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 1218930-80-3 C₁₇H₃₄N₂O₆Si 
• 149396-06-5 4-(tert-butyl-dimethyl-silanyloxy)-2-(2-nitro-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1257235-25-8 3-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzy1 ester 1-tert-butyl ester 
• 1257235-39-4 6-hydroxy-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester hydrochloride salt 
• 1257235-27-0 3-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 1257235-41-8 6-hydroxy-4-isopropylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 1257235-31-6 4-(2-amino-3,3-dimethyl-butyryl)-3-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 1257235-45-2 [1-(6-hydroxy-4-isopropylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester 
• 1257235-49-6 {1-[1-(6-hydroxy-4-isopropylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2,2-dimethyl-propylcarbamoyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 1257233-99-0 benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester 
• 1257235-29-2 4-(2-benzyloxycarbonylamino-3,3-dimethyl-butyryl)-3-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 1257235-35-0 (1-{1-[6-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propylcarbamoyl}-ethyl)-methyl-carbamic acid benzyl ester 
• 1257233-67-2 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-3-(4-fluorobenzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzylamide 
• 1257235-33-8 4-{2-[2-(benzyloxycarbonyl-methyl-amino)-propionylamino]-3,3-dimethyl-butyryl}-3-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 1257235-51-0 {1-[1-(6-benzylcarbamoyloxy-4-isopropylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2,2-dimethyl-propylcarbamoyl]-ethyl}-methyl-carbamic acid benzyl ester 
• 1257235-37-2 (1-{1-[4-benzylcarbamoyl-6-(4-fluoro-benzyloxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propylcarbamoyl}-ethyl)-methyl-carbamic acid benzyl ester 

Relevant academic research and scientific papers

IAP INHIBITORS

The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.

PREPARATION OF DIAZAPENTALENE DERIVATIVES VIA EPOXYDATION OF DIHYDROPYRROLES

The present invention relates to a process for preparing a compound of formula (I), wherein R1 Is Pg1 Or P1’; P1' is CO-hydrocarbyl; P2 is CH2, O or N-Pg2; and Pg 1 an

Synthesis and evaluation of cis-hexahydropyrrolo[3,2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

A stereoselective synthesis of functionalised cis-hexahydropyrrolo[3,2-b] pyrrol-3-ones has been developed through Fmoc and Cbz-protected intermediates 5 and 6. Building blocks 5 and 6 were prepared via the intramolecular cyclisation of anti-epoxide 17. T

BIOLOGICALLY ACTIVE COMPOUNDS

Compounds of general formula (I) wherein: Z = CR3R4, where R3 and R4 are independently chosen from CO-7-alkyl P1 = CR5R6, P2 = O, CR7R8/sup