648934-56-9Relevant articles and documents
cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo- hexahydropyrrolo[3,2-c]pyrazole based scaffolds: Design rationale, synthesis and cysteinyl proteinase inhibition
Wang, Yikang,Benn, Alex,Flinn, Nick,Monk, Tracy,Ramjee, Manoj,Watts, John,Quibell, Martin
, p. 1327 - 1331 (2007/10/03)
The 5,5-bicycles cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene 3 and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole 4 were designed as rotationally restricted templates towards the preparation of inhibitors of CAC1 cysteinyl proteinases. The design strategy was