64907-23-9Relevant academic research and scientific papers
25 - Hydroxy - 7 - keto cholesterol synthesis method
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Paragraph 0058; 0059, (2018/04/03)
The present invention relates to a synthesis method for 25-hydroxy-7-ketocholesterol. The method comprises: using a 25-hydroxycholesterol derivative as a raw material in an organic solvent, initiating by an initiator in the presence of an N-hydroxy catalyst; reacting 1-40 hours at a temperature of 0 DEG C-150 DEG C with air or oxygen; performing dehydration reaction for 1-20 hours by adding a dehydrant at a temperature of -20 DEG C-100 DEG C after completion of the reaction; then performing hydrolysis reaction for 1-2 hours at a temperature of 50 DEG C-80 DEG C; and obtaining 25-hydroxy-7-ketocholesterol after separation treatment of the reaction solution. The raw materials and reagents used in the present invention are readily available and environmentally-friendly. The synthesis method for 25-hydroxy-7-ketocholesterol provided by the present invention avoids the use of the metal Cr, the oxidant PCC and the like that pollute the environment seriously, and is good in reaction sclectivity, high in yield, low in cost, simple in treatment thereafter, less in three wastes, easy in product separation and high in purity.
N-Hydroxyphthalimide catalyzed allylic oxidation of steroids with t-butyl hydroperoxide
Zhao, Qian,Qian, Chao,Chen, Xin-Zhi
, p. 1 - 6 (2015/02/19)
A new and optimized procedure for the allylic oxidation of Δ5-steroids with t-butyl hydroperoxide in the presence of catalytic amounts of N-hydroxyphthalimide (NHPI) under mild conditions was developed, showing excellent regioselectivity and chemoselectivity (functional group compatibility). It was found that Co(OAc)2 could enhance the catalytic ability of NHPI resulting in better yields and shorter reaction times. The reaction mechanism and the scope of the reaction with a variety of Δ5-steroidal substrates were also investigated.
Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein
Ohgane, Kenji,Karaki, Fumika,Noguchi-Yachide, Tomomi,Dodo, Kosuke,Hashimoto, Yuichi
supporting information, p. 3480 - 3485 (2014/07/22)
Niemann-Pick disease type C is a fatal neurodegenerative disease, and its major cause is mutations in NPC1 gene. This gene encodes NPC1 protein, a late endosomal polytopic membrane protein required for intracellular cholesterol trafficking. One prevalent mutation (I1061T) has been shown to cause a folding defect, which results in failure of endosomal localization of the protein, leading to loss-of-function phenotype. We have previously demonstrated that several oxysterols and their derivatives act as pharmacological chaperones; binding of these compounds to NPC1I1061T mutant protein corrects the localization/maturation defect of the mutant protein. Here, we disclose detailed structure-activity relationships of oxysterol derivatives as pharmacological chaperones for NPC1I1061T mutant.
