6491-25-4 Usage
Uses
Used in Pharmaceutical Industry:
H-GLY-ALA-ALA-OH is used as a building block for the development of pharmaceuticals and other biologically active compounds. Its role in forming peptide bonds and potential biological activity make it a valuable component in the creation of new drugs and therapies.
Used in Peptide Synthesis Research:
H-GLY-ALA-ALA-OH is used as a building block in the study of peptide synthesis. Its structure allows researchers to investigate the properties and behaviors of peptides in various biological and chemical contexts, contributing to a better understanding of peptide synthesis and its applications.
Used in Biochemical Research:
H-GLY-ALA-ALA-OH is used as a tool in biochemical research to study the interactions and properties of peptides. Its composition of glycine and alanine allows for the exploration of peptide bond formation and the effects of different amino acid sequences on peptide behavior.
Check Digit Verification of cas no
The CAS Registry Mumber 6491-25-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,9 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6491-25:
(6*6)+(5*4)+(4*9)+(3*1)+(2*2)+(1*5)=104
104 % 10 = 4
So 6491-25-4 is a valid CAS Registry Number.
6491-25-4Relevant academic research and scientific papers
Methyl group steric effects on the kinetics of the copper(II)-tripeptide reactions with triethylenetetramine
Schwederski, Brigitte E.,Basile-D'Alessandro, Franco,Dickson, Peter N.,Lee, Hsiupu D.,Raycheba, John M. T.,Margerum, Dale W.
, p. 3477 - 3480 (2008/10/08)
Rates of reaction of triethylenetetramine (trien) with doubly deprotonated (tripeptido)cuprate(II) complexes are measured as a function of the number and position of methyl groups in the amino acid residues. Twelve tripeptides that consist of glycyl (G), L-alanyl (A), and α-aminoisobutyryl (Aib) residues are compared. The Cu(H-2Aib3)- complex reacts 8 orders of magnitude more slowly with trien than does the Cu(H-2G3)- complex. Methyl groups on the α-carbon of the second and third amino acid residues (from the amino terminus) decrease the rate of the trien substitution reaction to a much greater extent than methyl groups on the first residue. An empirical correlation between the second-order rate constant (Ktrien, M-1 s-1 at 25.0°C, pH ? 11) and the number and position of the methyl groups is found: log ktrien = 6.7 - 0.2C1 - 2.2C2 - 1.6C3, where Ci denotes the number of methyl groups in the ith amino acid residue. The enormous changes in reactivity are attributed primarily to steric effects in these ligand-ligand exchange reactions.
