64953-96-4

Upstream product

• 2362-62-1 4-methylthiobenzamide 
• 35199-18-9 4-chloromethyl-2-(4-methyl-phenyl)-thiazole 
• 74-88-4 methyl iodide 
• 55327-29-2 2-p-tolylthiazole-4-carbaldehyde 

Downstream Products

• 1637585-10-4 N-(1-(2-p-tolylthiazol-4-yl)ethyl)butyramide 
• 1637585-14-8 N-(1-(2-p-tolylthiazol-4-yl)ethyl)butyramide 
• 1637585-18-2 1-(2-p-tolylthiazol-4-yl)ethanamine 
• 1637585-22-8 1-(2-p-tolylthiazol-4-yl)ethanamine 
• 1637585-02-4 C₁₂H₁₂N₄S 
• 1637585-06-8 N-(1-(2-p-tolylthiazol-4-yl)ethyl)butyramide 
• 1017119-00-4 1-(2-p-tolylthiazol-4-yl)ethanamine 

Relevant academic research and scientific papers

Candida antarctica lipases acting as versatile catalysts for the synthesis of enantiopure (R)- and (S)-1-(2-phenylthiazol-4-yl)ethanamines This paper is dedicated to the anniversary of 95th birthday of Professor Valer Fǎrcǎ?anu.

The synthesis of both enantiomers of four new phenylthiazole-based amines by enantiomer-selective acylation of racemic amines and by hydrolysis of the corresponding racemic amides using lipase B from Candida antarctica (Novozyme 435) as chiral catalyst was performed with good yields and excellent enantioselectivities. In order to prevent the frequently occurring partial racemization of enantiopure amides during chemical hydrolysis to the corresponding (R)-amines, the deprotection of the N-acylated (R)-enantiomers by mild enzymatic hydrolysis with lipase A from C. antarctica immobilized on Celite was also developed.

Heterocycles 32. Efficient kinetic resolution of 1-(2-arylthiazol-4-yl) ethanols and their acetates using lipase B from Candida antarctica

In this paper we describe the chemoenzymatic synthesis of new enantiomerically enriched (R)- and (S)-1-(2-arylthiazol-4-yl)ethanols and their acetates by enzymatic enantioselective acetylation of the racemic alcohols rac-2a-d and by methanolysis of the corresponding racemic esters rac-3a-d mediated by lipase B from Candida antarctica (CaL-B) in non-aqueous media. In terms of stereoselectivity and activity, both procedures, acylation and alcoholysis, gave similar good results (50% conversion, E 〉 200). The absolute configuration of the kinetic resolution products was determined by a detailed 1H NMR study of the Mosher's derivatives of (S)-2b.