64954-57-0

Upstream product

• 94992-57-1 (R)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate 
• 66209-47-0 (1R,9R,10S)-N-cyclobutylformyl-9,10-dihydroxy-1-p-methoxybenzyl-decahydroisoquinoline 

Downstream Products

• 50807-67-5 14β-Hydroxy-3-methoxymorphinan 

Relevant academic research and scientific papers

Preparation method of butorphinol decyclobutyl impurity compound

The invention relates to the technical field of organic synthesis, and provides a preparation method of a butorphinol decyclobutyl impurity compound. The preparation of the impurity is always a difficult point in the related technical field, and the preparation of the impurity is not too long in reaction route or too low in yield. The impurity can be simply, conveniently and efficiently synthesized; a compound 1 is catalyzed by strong Lewis acid and reacts with a reducing agent to form a butorphinol decyclobutyl impurity intermediate (compound 2), and the high-purity butorphinol decyclobutyl impurity (compound 4) is obtained through cyclization reaction and demethoxylation reaction without column chromatography purification.

AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE

The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),