64957-08-0

Basic information

• Product Name: L-Alanine, 3-(chlorosulfonyl)-N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester
• CAS NO: 64957-08-0
• Molecular Formula: C18H18ClNO6S
• Molecular Weight: 411.863
• Mol File: 64957-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Alanine, 3-(chlorosulfonyl)-N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, 3-(chlorosulfonyl)-N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester(64957-08-0)
• EPA Substance Registry System: L-Alanine, 3-(chlorosulfonyl)-N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester(64957-08-0)

Safety Data

• Hazardous Substances Data: 64957-08-0(Hazardous Substances Data)

Upstream product

• 6968-11-2 N,N'-bis(benzyloxycarbonyl)-L-cystine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 64957-09-1 N,N'-bis(benzyloxycarbonyl)-L-cystine dibenzyl ester 

Downstream Products

• 152871-65-3 (R)-2-Benzyloxycarbonylamino-3-(2,4,6-trimethoxy-benzylsulfamoyl)-propionic acid 
• 152871-64-2 (S)-2-Benzyloxycarbonylamino-3-(2,4,6-trimethoxy-benzylsulfamoyl)-propionic acid benzyl ester 
• 65034-39-1 C₂₄H₂₇N₃O₉S 
• 64957-22-8 C₂₅H₂₄FN₃O₉S₂ 
• 64957-12-6 C₂₃H₂₉N₃O₈S 
• 64957-11-5 (R)-2-benzyloxycarbonylamino-3-sulfamoyl-propionic acid benzyl ester 
• 97817-93-1 (R)-2-benzyloxycarbonylamino-3-sulfamoyl-propionic acid amide 
• 890040-26-3 2(R)-benzyloxycarbonylamino-3-(morpholine-4-sulfonyl)propionic acid benzyl ester 
• 64957-16-0 (R)-2-Benzyloxycarbonylamino-3-hydroxysulfamoyl-propionic acid benzyl ester 
• 64957-21-7 (R)-2-Benzyloxycarbonylamino-3-(4-fluorosulfonyl-benzylsulfamoyl)-propionic acid benzyl ester 
• 64957-17-1 (R)-2-Benzyloxycarbonylamino-3-benzyloxysulfamoyl-propionic acid benzyl ester 
• 64957-19-3 (R)-2-Benzyloxycarbonylamino-3-(2-chloro-ethylsulfamoyl)-propionic acid benzyl ester 
• 903881-41-4 (R)-2-Benzyloxycarbonylamino-3-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-propionic acid 

Relevant articles and documents

Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors

Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation of the adaptive immune system and many major diseases. Here, we used NMR fragment screening and crystal structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymatic Ki values and nanomolar functional activity in human Raji cells. Noncovalent fragment hits revealed binding hotspots, while the covalent inhibitor structure-activity relationship enabled efficient potency optimization.