649719-48-2Relevant academic research and scientific papers
Mechanochemical Synthesis of Short DNA Fragments
Thorpe, James D.,O'Reilly, Daniel,Fri??i?, Tomislav,Damha, Masad J.
supporting information, p. 8857 - 8861 (2020/07/08)
We demonstrate the first mechanochemical synthesis of DNA fragments by ball milling, enabling the synthesis of oligomers of controllable sequence and length using multi-step, one-pot reactions, without bulk solvent or the need to isolate intermediates. Me
Solution-phase synthesis of phosphorothioate oligonucleotides using a solid-supported acyl chloride with H-phosphonate chemistry
Adamo, Ilaria,Dueymes, Cecile,Schoenberger, Andreas,Navarro, Aude-Emmanuelle,Meyer, Albert,Lange, Meinolf,Imbach, Jean-Louis,Link, Fritz,Morvan, Francois,Vasseur, Jean-Jacques
, p. 436 - 448 (2007/10/03)
The synthesis of oligonucleotides from dimers to a hexamer by a H-phosphonate approach in solution using solid-supported acyl chloride is reported herein. This strategy avoids the use of chromatography. The work-ups have been simplified and involve filtra
A solid supported reagent for internucleoside H-phosphonate linkage formation
Mohe, Nikhil,Heinonen, Petri,Sanghvi, Yogesh S.,Stroemberg, Roger
, p. 897 - 899 (2007/10/03)
A fast and convenient procedure for synthesis of dinucleoside H-phosphonates is obtained through use of the novel polystyrene supported 5-carboxy-5-methyl-2-oxo-2-chloro-1,3,2-dioxaphosphorinane reagent. Virtually quantitative H-phosphonate condensations
