649727-81-1

Upstream product

• 196795-17-2 (4aS,6R,9aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-hexahydro-1,5-dioxa-benzocyclohepten-7-one 
• 649727-80-0 tert-Butyl-((4aS,6S,9aR)-7-methylene-octahydro-1,5-dioxa-benzocyclohepten-6-ylmethoxy)-diphenyl-silane 

Downstream Products

• 649727-83-3 (4aS,6R,7S,9aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methyl-octahydro-1,5-dioxa-benzocyclohepten-7-ol 
• 254442-46-1 (4aS,6R,7S,9aR)-6-[(2R,3S)-3-(tert-butyldiphenylsilyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiran-2-ylmethyl]-7-methyl-7-(trimethylsilyloxy)octahydro-1,5-dioxabenzocycloheptene 

Relevant academic research and scientific papers

Synthesis of trans-fused polycyclic ethers with angular methyl groups using sulfonyl-stabilized oxiranyl anions

An efficient method has been developed for the synthesis of trans-fused tetrahydropyrans with angular methyl groups adjacent to the ring oxygen. The procedure involves the coupling reaction of a sulfonyl-stabilized oxiranyl anion with an appropriate triflate followed by 6-endo cyclization, and is effective for the construction of 6/6- and 6/7/6-cyclic ether ring systems with sterically congested 1,3-diaxial methyl groups.