649737-05-3Relevant articles and documents
Visible Light-Mediated Coupling of Thioureas and 1,3-Dicarbonyls: Towards a Leaving Group-Free Synthesis of Aminothiazoles
Roslan, Irwan Iskandar,Ng, Kian-Hong,Gondal, Mohammed Ashraf,Basheer, Chanbasha,Dastageer, Mohamed A.,Jaenicke, Stephan,Chuah, Gaik-Khuan
, p. 1584 - 1589 (2018)
A synthesis of aminothiazoles from various 1,3-dicarbonyls and thioureas without a leaving group has been developed. The reaction is photocatalyzed by tetraiodofluorescein, an organic dye. Under irradiation with green LEDs, a sulfur radical is generated in situ from thiourea, followed by addition to the enol tautomer, forming the aminothiazole backbone. This novel strategy provides a greener alternative to the traditional leaving group protocols, with excellent atom economy. (Figure presented.).