649737-38-2Relevant academic research and scientific papers
Diastereoselective syntheses of chroman spiroketals via [4 + 2] cycloaddition of enol ethers and o-quinone methides
Marsini, Maurice A.,Huang, Yaodong,Lindsey, Christopher C.,Wu, Kun-Liang,Pettus, Thomas R. R.
supporting information; experimental part, p. 1477 - 1480 (2009/04/10)
(Chemical Equation Presented) A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature o-QM generation in situ allows for the kinetic, diastereoselective construction of these motifs, providing entry to a number of unusual chroman spiroketal natural products.
Acylaminothiazole derivatives, preparation and therapeutic use thereof
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Page/Page column 13-14, (2008/06/13)
This invention discloses and claims a compound conforming to the general formula (I): Wherein R1, R2, R′2, R3, R4 and R5 are as described herein. The compounds of the present invention exhibit an inhibitory effect on the production of β-amyloid peptide (β-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.
